Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1994-05-20
1997-04-22
Kim, Kay K. A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530403, 530405, 530406, 530408, 530409, 530410, 530411, 4241931, 4241941, 42419711, 4242341, 4242371, 4242411, 4242441, 4242561, 4242601, C07K 1702, A61K 39385
Patent
active
056230575
ABSTRACT:
A novel conjugate vaccine comprising partially hydrolyzed, highly purified, capsular polysaccharide (Ps) from Streptococcus pneumoniae bacteria (pneumococci, Pn) linked to an immunogenic carrier protein, is produced by a new process. The conjugate is useful in the prevention of pneumococcal infections. Vaccines comprising a mixture of from one to ten different pneumococcal polysaccharide-immunogenic protein (Pn-Ps-PRO) conjugates induce broadly protective recipient immune responses against the cognate pathogens from which the polysaccharide components are derived. Young children and infants younger than 2 years old, normally unable to mount a protective immune response to the Pn-Ps alone, exhibit protective immune responses upon vaccination with these Pn-Ps-PRO conjugates.
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Burke Pamela D.
Hagopian Arpi
Hennessey, Jr. John P.
Ip Charlotte C.
Kniskern Peter J.
Giesser Joanne M.
Kim Kay K. A.
Merck & Co. , Inc.
Tribble Jack L.
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