PNA monomers with electron donor or acceptor

Details PNA monomers with electron donor or acceptor PNA monomers with electron donor or acceptor

1997-02-24

2000-09-12

Marschel, Ardin H.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

435 6, 436501, 530350, C07K 500

Patent

active

061179736

ABSTRACT:
New electron transfer moiety labeled nucleic acid analogue probes are provided that can be used in methods for determining nucleic acids in a sample. The new probes can be prepared using novel monomer subunits in a chemical synthesis route. The nucleic acids can be determined by binding the probe molecules to the nucleic acid and inducing electron transfer within the complex formed. The occurrence of the electron transfer is determined as a measure of the nucleic acid.

REFERENCES:
patent: 5770369 (1998-06-01), Meade et al.
Dreyer et al., Proceedings of the National Acad. of Sci (USA), vol. 82, pp 968-972, 1985.
Egholm et al., Nature, vol. 365, pp 566-568, 1993.
Egholm et al., Journal of the American Chemical Society, vol. 114, No. 5, pp. 1895-1897, 1992.
Science, vol. 262, Nov. 12, 1993, Murphy et al., "Long-Range Photoinduced Electron Transfer Through a DNA Helix".
Nature Biotechnology, vol. 14, Mar. 1996, Tyagi et al., "Molecular Beacons: Probes that Fluoresce upon Hybridization".
International Publication No. WO 92/20703 published Nov. 26, 1992.
International Publication No. WO 92/20702 published Nov. 26, 1992.
International Publication No. WO 95/15971 published Jun. 15, 1995.
International Publication No. WO 96/11205 published Apr. 18, 1996.

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