PNA chip using zip-codes and fabrication method thereof

Details PNA chip using zip-codes and fabrication method thereof PNA chip using zip-codes and fabrication method thereof

2005-04-25

2010-02-09

Moran, Marjorie (Department: 1631)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C977S792000, C977S791000, C156S330000, C156S327000

Reexamination Certificate

active

07659064

ABSTRACT:
A PNA zip-code chip in which PNA zip-code probes are immobilized on a substrate at high density using an epoxy compound as a linker, and method for fabricating such PNA chip. The use of PNA provides the chip with superior properties to DNA chips, allowing precise diagnosis of congenital diseases or base mutations with much higher sensitivity than is achievable with a DNA chip. The use of the PNA zip-code chip enables diagnosis of gene mutations in a simple manner, using only hybridization reaction, without the difficulties associated with processes in which probes must be immobilized directly on a substrate every time the target gene changes.

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