PML-RARA targeted ribozymes

Details PML-RARA targeted ribozymes PML-RARA targeted ribozymes

1994-04-25

1997-06-17

LeGuyader, John

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 6, 435 9131, 4351721, 4351723, 4352401, 4353201, 536 231, 536 232, 536 245, 514 44, C12Q 168, C12N 1585, C07H 2104, A61K 4800

Patent

active

056396554

ABSTRACT:
An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of promyelocytic leukemia.

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Perrotta and Been, 31 Biochemistry 16, 1992, "Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .delta. Virus RNA Sequence".
Hampel and Tritz, 28 Biochemistry 4929, 1989, "RNA Catalytic Properties of the Minimum (-)sTRSV Sequence".
Hampel et al., 18 Nucleic Acids Research 299, 1990, "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA".
Weerasinghe et al., 65 Journal of Virology 5531, 1991, "Resistance to Human Immunodeficiency Virus Type 1 (HIV-1) Infection in Human CD4.sup.+ Lymphocyte-Derived Cell Lines Conferred by Using Retroviral Vectors Expressing an HIV-1 RNA-Specific Ribozyme".
Mamone et al., "Design of Hammerhead Ribozymes Targeted to Sequences in HIV, HSV, and the Rat Anf Gene", Abstract of Keystone, CO (May 27, 1992).
Pavco et al., "Regulation of Self-Splicing Reactions by Antisense RNA", Abstract of Keystone, CO (May 27, 1992).
Haseloff and Gerlach, 334 Nature 585, 1988, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities".
Guerrier-Takada et al., 35 Cell 849, 1983, "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme".
Rossi et al., 8 Aids Research and Human Retroviruses 183, 1992, "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems".
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