Pluripotential embryonic stem cells and methods of making same

Details Pluripotential embryonic stem cells and methods of making same Pluripotential embryonic stem cells and methods of making same

1995-06-05

1997-09-23

Ziska, Suzanne E.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 11, 43524021, C12N 500, A01N 102

Patent

active

056703724

ABSTRACT:
The present invention provides a non-mouse pluripotential embryonic stem cell which can be maintained on feeder layers for at least 20 passages and give rise to embryoid bodies and multiple differentiated cell phenotypes in monolayer culture. The invention further provides a method of making a pluripotential embryonic stem cell comprising administering a growth enhancing amount of basic fibroblast growth factor, leukemia inhibitory factor, membrane associated steel factor, and soluble steel factor to primordial germ cells under cell growth conditions, thereby making a pluripotential embryonic stem cell.

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