Surgery – Miscellaneous – Methods
Patent
1997-12-15
2000-07-04
Nguyen, Dinh X.
Surgery
Miscellaneous
Methods
623 1111, 623 1611, A61B 1900
Patent
active
06082364&
ABSTRACT:
Pluripotent stem-like cells obtained from bone marrow differentiate into osteocytes, chondrocytes and adipocytes, depending on the environment encountered and treatment. If systemically administered, the cells "home", that is migrate, to bone marrow. The cells may be transformed with recombinant DNA for the expression of both reporter genes, and biological factors, such as growth factors. The cells may be systemically administered to treat osteoporosis, osteolysis, improve bone implant adherence, augment bone growth or bone repair, augment cartilage repair, augment fat production for, e.g., breast augmentation, and the like.
REFERENCES:
patent: 5197985 (1993-03-01), Caplan et al.
patent: 5226914 (1993-07-01), Caplan et al.
patent: 5486359 (1996-01-01), Caplan et al.
patent: 5591625 (1997-01-01), Gerson et al.
patent: 5693622 (1997-12-01), Wolff et al.
patent: 5763416 (1998-06-01), Bonadio et al.
patent: 5785965 (1998-07-01), Pratt et al.
patent: 5837283 (1998-11-01), McDonald et al.
M.J. Devine, et al., Bone Marrow Stem Cells Localize to Fractures in a Mouse Model, 43.sup.RD Annual Meeting, Orthopaedic Research Society, Feb. 9-13, 1997.
G.A. Dahir, et al., Preparation of a Cloned Osteogenic Bone Marrow Cell Line with a Traceable Genetic Market, 41.sup.ST Annual Meeting, Orthopaedic Research Society, Feb. 13-16, 1995.
Anderson, P., et al., "Cultures of a Cloned Bone Marrow Cell are Chondrogenic," 41.sup.ST Annual Meeting Ortho. Res. Soc. Trans., 20(2):462, Feb., 1995.
C.C. Su, et al. Bone Marrow Osteoprogenitor Cells Adhere to Titanium Implants, 42.sup.ND Annual Meeting, Orthopaedic Research Society, Feb. 19-22, 1996.
Q. Cui, et al., Steriod-Induced Expression of a Fat-Specific Gene by a Multipotentila Cell Cloned from Bone Marrow Stroma, 41.sup.ST Annual Meeting, Orthopaedic Research Society, Feb. 13-16, 1995.
Q. Cui, et al., A Transfected Osteoprogenitor Cell Beomces Adipocytic in Response to Steroids in Vitro and in vivo, 43.sup.RD Annual Meeting, Orthopaedic Research Society, Feb. 9-13, 1997.
R.E. Topping, et al., Effect of Factors Influencing Type X Collagen Expression in Periosteum, 41.sup.ST Annual Meeting, Orthopaedic Research Society, Feb. 13-16, 1995.
David R. Diduch, et al., Two Cell Lines from Bone Marrow that Differ in Terms of Collagen Synthesis, Osteogenic Characteristics, and Matrix Mineralization, The Journal of Bone and Joint Surgery, vol. 75-A, No. 1, pp. 92-105, Jan. 1993.
Q. Cui, et al., Steriod-Induced Adipogenesis in a Pluripotential Cell Line from Bone Marrow, The Journal of Bone and Joint Surgery, vol. 79-A, No. 7, pp. 1054-1063, Jul. 1997.
American Type Culture Collection, ATCC Designation CRL-12424, Nov. 7, 1997.
Su, C. C., Cui, Q., Wang, G. J., Surprenant, H. P., Collier, J. P., & Balian, G., "Bone Marrow Osteoprogenitor Cells Adhere to Titanium Implants," 42.sup.nd Annual Meeting, Orthopaedic Research Society, Feb. 19-22, 1996, p. 91-16.
Dahir G. A., Simon, Jr. C. G., Lillard T. S.,& Balian G. "Preparation of a Cloned Osteogenic Bone Marrow Cell Line with a Traceable Genetic Marker" 41.sup.st Annual Meeting, Orthopaedic Research Society, Feb. 13-16, p. 277 .
Balian Gary
Diduch David
Hahn Chang
Wang Gwo-Jaw
Musculoskeletal Development Enterprises, LLC
Nguyen Dinh X.
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