Pluripotent mesenchymal stem cells and methods of use thereof

Details Pluripotent mesenchymal stem cells and methods of use thereof Pluripotent mesenchymal stem cells and methods of use thereof

1996-05-20

1998-10-27

Saunders, David

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435349, 435380, C12N 500, C12N 502

Patent

active

058277358

ABSTRACT:
A scar inhibitory factor protein isolate from mammalian basement membranes is provided that inhibits lineage commitment and differentiation of stem cells in vitro and in vivo. The protein isolate is characterized by its ability to inhibit stem cell commitment to a fibroblastic-scar phenotype without killing the cells, thus allowing their differentiation into normal tissue phenotypes. SIF thus limits the amount of scar tissue formation at the site of delivery, while maximizing the potential for the stem cells to differentiate into other tissue phenotypes (muscle, cartilage, bone, fat, etc.). Therefore, it is useful in treating numerous disorders and injuries that currently result in scar tissue or fibrous adhesion formation. The protein isolate can be administered in various modalities in vivo, i.e., as a transdermal patch, incorporated into wound dressings, incorporated into absorbable suture material, incorporated into a bioerodible polymer matrix by itself or interspersed with differentiation factors near the site of tissue injury, sprayed onto prosthetic implants, and can be administered directly to cells cultured in vitro.

REFERENCES:
patent: 5041138 (1991-08-01), Vacanti et al.
patent: 5197985 (1993-03-01), Caplan et al.
patent: 5226914 (1993-07-01), Caplan et al.
patent: 5328695 (1994-07-01), Lucas et al.
patent: 5486359 (1996-01-01), Caplan et al.
Quinn, LS et al. Nature. 310:692-694, Feb. 21, 1985.
Young et al. (1992) J. Tiss. Cult. Meth. 14:85-92.
Young et al. (1992) J. Tiss. Cult. Meth. 14:31-36.
Young et al. (1991) J. Tiss. Cult. Meth. 13:275-84.
Young et al. (1989) J. Morphology 201:85-103.
Young et al. (1988) Connective Tissure Res. 17:99-112.
Bauer et al. (1985) Proc. Natl. Acad. Sci. USA 82:4132-6.
Baumann et al. (1986) Geburtsh Frauenheilkd 45:234-6.
Buntrock et al. (1984) Exp. Pathol. 26:247-54.
Carpenter et al. (1979) Annu. Rev. Biochem. 48:193-216.
Cohen et al. (1990) Plastic Surgery, vol. I, General Principles, pp. 732-747.
Connolly et al. (1960) Int. Abstr. Surg. 110:417-31.
Cutroneo et al. (1981) Coll. Relat. Res. 1:557-68.
Cutroneo et al. (1986) The Biology of the Extracellular Matrix, pp. 119-176.
Deuel et al. (1981) Proc. Natl. Acad. Sci. USA 78:4584-7.
Duncan et al. (1984) J. Invest Dermatol. 83:377-84.
Edwards et al. (1958) New Eng. J. Med. 259:224-33, 275-85.
Ehrlich et al. (1984) Soft and Hard Tissue Repair: Biological and Clinical Aspects, pp. 533-553.
Ellis (1971) Surg. Gynec. Obstet. 133:497-511.
Engrav et al. (1989) Ann. Plast. Surg. 23:245-8.
Gabbiani et al. (1971) Experientia 27:549-50.
Gabbiani et al. (1972) Am J. Pathol. 66:131-8.
Gauwerky et al. (1988) Huamn Reprod. 3:327-30.
Gauwerky et al. (1990) Arch. Gynecol. Obstet. 247:161-6.
Golan et al. (1991) Int. J. Fert. 36:317-20.
Gospodarowicz et al. (1986) Cell Differentiation 19:1-17.
Graham et al. (1984) J. Orthop. Res. 1:251-6.
Graham et al. (1984) Soft and Hard Tissue Repair: Biological and Clinical Aspects, pp. 361-79.
Grillo et al. (1959) Proc. Soc. Exp. Biol. Med. 101:268-70.
Grotendorst et al. (1985) J. Clin. Invest. 76:2323-9.
Heldelin et al. (1983) Scand. J. Plast. Reconstr. Surg. 17:179-81.
Hunt et al. (1969) Ann. Surg. 170:633-41.
Hunt et al. (1984) Surgery 96:48-54.
Johnson et al. (1928) Surg. Gyn. Obstet. 45:612-9.
Johnson (1928) N. Eng. J. Med. 199:661-4.
Knighton et al. (1982) Ann. Surg. 196:379-87.
Knighton et al. (1986) Ann. Surg. 204:322-30.
Knighton et al. (1988) Growth Factors and Other Aspects of Wound Healing: Biological and Clinical Impications, pp. 319-329.
Lacey (1935) Ann. Surg. 101:529-35.
Lindenberg et al. (1984) Ann. Chr. Gynaecol. 73:11-3.
Lindenberg et al. (1985) Acta Chir. Scand. 151:525-7.
Luciano et al. (1982) Amer. J. Obstet. Gynecol. 146:88-92.
Martinent et al. (1985) Nature 31:158-60.
Narayanan et al. (1985) Biochem. Biophys. Res. Comm. 131:1028-32.
Oka et al. (1983) J. Clin. Invest. 72:249-59.
Orda et al. (1974) J. Surg. Res. 17:365-74.
Peacock et al. (1990) Plastic Surgery, vol. I General Principles, pp. 161-185.
Pffefer et al. (1980) Fertil. Steril. 33:245-56.
Pierce et al. (1988) J. Exp. Med. 167:974-87.
Postlethwaite et al. (1984) J. Immunol. 132:2470-7.
Richey et al. (1989) Ann. Plast. Surg. 23:159-65.
Rosenbloom et al. (1983) Cell Immunol. 81:192-8.
Ross et al. (1978) Cell 14:203-10.
Ross et al. (1987) Ann. Rev. Med. 38:71-9.
Rudolph et al. (1978) Plast. Reconstr. Surg. 62:185-96.
Russell et al. (1977) J. Cell Physiol. 93:389-94.
Scher et al. (1979) Biochem. Biophys. Acta 560:217-41.
Seppa et al. (1982) J. Cell. Biol. 92:584-8.
Shimokado et al. (1985) 43:277-86.
Simpson et al. (1972) J. Clin. Invest. 51:2009-23.
Soules et al. (1982) Am. J. Obstet. Gynecol. 143:829-34.
Sporn et al. (1986) Science 233:532-4.
Spencer (1977) Reconstructive Microsurgery, pp. 342-349.
Sprugel et al. (1988) Growth Factors and Other aspects of Wound Healing: Biological and Clinical Implicationsl pp. 77-91.
Staindl et al. (1981) Arch. Otorhinolaryngol. 233:105-66.
Swolin (1966) Acta Obstet. et Gynecol. Scand. 45:473-98.
Topol et al. (1981) Plast. Reconstr. Surg. 68:227-30.
Van Winkle (1967) Surg. Gynecol. Obstet. 125:131-42.
Wahl et al. (1987) Proc. Natl. Acad. Sci. USA 84:5788-92.
Weiss et al. (1944) Proc. Soc. Exp. Biol. 55:77-80.
Williams et al. (1976) Plast. Reconstr. Surg. 57:562-9.
Yaita et al. (1975) Japanese J. Surg. 5:56-63.

Affiliated with

Also associated with

Rating

Pluripotent mesenchymal stem cells and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pluripotent mesenchymal stem cells and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pluripotent mesenchymal stem cells and methods of use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1613261