Plipastatin and method for preparation thereof

Details Plipastatin and method for preparation thereof Plipastatin and method for preparation thereof

1985-11-26

1988-05-03

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C07K 512

Patent

active

047421550

ABSTRACT:
Plipastatin represented by the general formula ##STR1## wherein R.sub.1 is --C.sub.13 H.sub.27 or --C.sub.14 H.sub.29 ; and R.sub.2 is Ala or Val, or salts thereof, which is prepared by culturing a Plipastatin-producing strain belonging to the genus Bacillus to produce and accumulate Plipastatin in a cultured broth and then isolating Plipastatin from the cultured broth. Plipastatin exhibits an enzyme inhibiting activity against phospholipase A.sub.2, C and D and which will be useful as an immunosuppressive agent or as a type I anti-allergic agent.

REFERENCES:
Biological Abstrs., vol. 82 (1986) 95952; 95953; 95954.

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