Pleasant-tasting aqueous liquid composition of a bitter-tasting

Details Pleasant-tasting aqueous liquid composition of a bitter-tasting Pleasant-tasting aqueous liquid composition of a bitter-tasting

1996-08-07

1998-06-09

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514179, 514629, 514718, A61K 31505, A61K 3156, A61K 3116, A61K 31075

Patent

active

057634491

ABSTRACT:
A liquid pharmaceutical composition is contemplated that comprises a pharmaceutically effective amount of a bitter tasting drug dissolved or dispersed in an aqueous medium that is free of ethanol. That aqueous medium consists essentially of water, about 5 to about 30 weight percent polyvinylpyrrolidone, about 45 to about 55 weight percent of a C.sub.3 -C.sub.6 polyol, about 0.01 to about 0.5 weight percent ammonium glycyrrhizinate and one or more flavorants. The liquid composition is transparent and has a pleasant taste.

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Horn et al., J. Pharm. Sci., 71(9):1021-1026 (1982).
Buhler, Kollidon, BASF, Ak,tiengesellshaft, Ludwigshafen, Germany, pp. 39-42, 70-72, 113-115 (Aug., 1992).
Gennaro, Alfonso R., ed., Remington's Pharmaceutical Sciences, 18th ed., Mack Publishing Company (Easton, Pennsylvania: 1989), pp. 1290-1296.

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