Platinum-polymer complexes and their use as antitumor agents

Details Platinum-polymer complexes and their use as antitumor agents Platinum-polymer complexes and their use as antitumor agents

1988-05-11

1990-06-05

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514492, 514908, 424 78, 556137, C07F 1500, A61K 3128

Patent

active

049315536

ABSTRACT:
Platinum(amine) complexes, when covalently linked to a water-soluble, biodegradable or biostable polymer, exhibit high antitumor activity at low dosages of platinum against L1210 and solid tumors. The complexes are platinum square planar complexes and octahedral structures of the formulae ##STR1## wherein A.sub.2 represents either 2 ammonia ligands, 2 monodentate amine ligands or a single bidentate amine ligand; P is either a biodegradable or a biostable but biocompatible polymer having pendent anionic groups which form covalent linkages with Pt; o is a positive integer and X is an anionic ligand.

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