Platinum(IV)-diamine complexes, a process for the preparation th

Details Platinum(IV)-diamine complexes, a process for the preparation th Platinum(IV)-diamine complexes, a process for the preparation th

1981-02-06

1984-02-14

Sneed, Helen M. S.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

260429R, C07F 1500, A61K 3128

Patent

active

044316666

ABSTRACT:
Platinum(IV)-diamine-complexes, a process for the preparation thereof, a process for the preparation of a medicine using such a platinum(IV)-diamine-complex for the treatment of malignant tumors in mice as well as the shaped medicine thus obtained.
This invention relates to novel platinum-diamine complexes, a pharmaceutical composition using the novel complexes and methods of treating malignant tumors in mice using the pharmaceutical composition.

REFERENCES:
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patent: 4140707 (1979-02-01), Cleare et al.
patent: 4228090 (1980-10-01), Hydes et al.
patent: 4250189 (1981-02-01), Hydes et al.
Braddock et al., Chemico-Biological Interactions, vol. 11, No. 3, pp. 158-159 (1975).
Van Kralingen, C. G., Antitumor Platinum Compounds; Synthesis, Structure and Biological Activity, No. 7, 1979.
B. Rosenberg and L. Van Camp, Cancer Research 30 (1970) 1799-1802.
A. P. Zipp and S. G. Zipp, J. Chem. Ed., 54 (12) (1977) p. 739.
M. L. Tobe and A. R. Khokhar, J. Clinical Hematol. Oncol., 7 (1) (1977), pp. 114-134.
Appleton, T. C. and Hall, J. R., Inorganic Chemistry, vol. 11, No. 1, 1972, pp. 112-117.

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