Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai
Reexamination Certificate
2004-11-24
2009-08-18
Gonzalez, P. Nazario (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heavy metal containing doai
C556S028000, C556S136000, C556S137000, C546S005000, C548S104000
Reexamination Certificate
active
07576126
ABSTRACT:
The invention relates to a method for the preparation of platinum (II) complexes, in particular dicarboxylatoplatinum (II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate (II) species with a suitable neutral bidentate ligand to form a neutral dicarboxylatoplatinum (II) complex and, if necessary, recrystallising the product to form a pure dicarboxylatoplatinum (II) complex containing a neutral bidentate ligand. The invention also relates to a method for producing a bis-dicarboxylatoplatinate (II) species, and to new platinum (II) complexes that can be made by the method of the invention.
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Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Song, Rita et al.: “Synthesis and selective tumor targeting properties of water soluble porphyrin-Pt(II) conjugates. 'Erratum to document cited in CA137:362598!” XP002317067 retrieved from STN Database accession No. 2002:85473 abstract & Journal of Inorganic Biochemistry, 92(3-4), 200 Coden: JIBIDJ; ISSN: 0162-0134, 2002, & Database CA ′Online! Chemical Anstracts Service, Columbus, Ohio, US; Song, Rita et al.: “Synthesis and selective tumor targeting properties of water soluble porphyrin-Pt(II) conjugates” retrieved from STN Database accession No. 2002: 249587 abstract & Journal of Inorganic Biochemistry, 89(1-2), 83-88 Coden: JIBIDJ; ISSN: 0162-0134, 2002.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Khuzaie, Rula F. et al.: “Screening for anticomplementary activity of some platinum (II) and palladium (II) complexes with various donor ligands and anions” XP002317068 retrieved from STN Database accession No. 2002: 445382 abstract & Oriental Journal of Chemistry, 18(1), 1-6 Coden: 0JCHEG; ISSN: 0970-020X, 2002.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Rashan, Luay J. et al.: “In vitro antitumor activity of platinum (II) complexes with various nitrogen containing ligands” XP002317069 retrieved from STN Database accession No. 1998:5223331 abstract & Biologia (Bratislava), 53(3), 349-352 Coden: BLOAAO; ISSN: 0006-3088, 1998.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Prignano, Andrea L. et al.: “Silica-anchored bis(trialkylphosphine) platinum oxalate: a photogenerated catalyst for olefin hydrosilation” XP002317070 retrieved from STN Database accession No. 1987:77537 abstract & Monatshefte Fuer Chemie, 117(5), 617-19 Coden: MOCMB7; ISSN: 0026-9247, 1986, 1986.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Puniyani, Sushil et al.: “Platinum (II) complexes of cyclohexanone and cyclopentanone thiosemicarbazones” XP002317071 retrieved from STN Database accession No. 1985:447222 abstract & Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 24a(3), 240-1 Coden: IJCADU; ISSN: 0376-4710, 1985.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Syamal, A. et al.: “Synthesis of new platinum (II) complexes with ethanethiolamine, o-aminothiophenol and bidentate carboxylic acids” XP002317072 retrieved from STN Database accession No. 1983: 209058 abstract & Revue De Chimie Minerale, 20(1), 123-8 Coden: RVCMA8; ISSN: 0035-1032, 1983.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Uttecht, j.-g. et al.: Synthesis, vibrational spectra and normal coordinate analysis of (n-Bu4N)2 'Pt(SCN)n(ox), n-2, 4, and crystal structure of '(C5H5N)2CH2 'Pt(SCN)4(ox) XP002317073 retrieved from STN Database accession No. 2002: 781520 abstract & Zeitschrift Fuer Naturforschung, B: Chemical Sciences, 57(9), 1036-1042 Coden: ZNBSEN; ISSN: 0932-0776, 2002.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Mizuno, Masagi: “Linear chain compound bisoxalatoplatinate complexes” XP002317074 retrieved from STN Database accession No. 1989:432596 abstract & Kagaku Kogyo Shiryo (Tsukuba, Japan), 23(5), 201-16 CODEN: KKSHEP; ISSN: 0288-8882, 1989.
Thornber, C.W.: “Isoterism and Molecular Modification in Drug Design”, Chemical Society Reviews, Chemical Society, London, GB, vol. 8, No. 4, 1979, pp. 563-580, XP000953019 ISSN: 0306-0012 p. 564, item 5).
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Song, Rita et al.: “Synthesis and selective tumor targeting properties of water soluble porphyrin-Pt(II) conjugates. ′Erratum to document cited in CA137:362598!” XP002317067 retrieved from STN Database accession No. 2002:85473 abstract & Journal of Inorganic Biochemistry, 92(3-4), 200 Coden: JIBIDJ; ISSN: 0162-0134, 2002.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Khuzaie, Rula F. et al.: “Screening for anticomplementary activity of some platinum (II) and palladium (II) complexes with various donor ligands and anions” XP002317068 retrieved from STN Database accession No. 2002: 445382 abstract & Oriental Journal of Chemistry, 18(1), 1-6 Coden: 0JCHEG; ISSN: 0970-020X, 2002.
Database CA ′Online⇄ Chemical Abstracts Service, Columbus, Ohio, US; Rashan, Luay J. et al.: “In vitro antitumor activity of platinum (II) complexes with various nitrogen containing ligands” XP002317069 retrieved from STN Database accession No. 1998:522331 abstract & Biologia (Bratislava), 53(3), 349-352 Coden: BLOAAO; ISSN: 0006-3088, 1998.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Prignano, Andrea L. et al.: “Silica-anchored bis(trialkylphosphine) platinum oxalate: a photogenerated catalyst for olefin hydrosilation” XP002317070 retrieved from STN Database accession No. 1987:77537 abstract & Monatshefte Fuer Chemie, 117(5), 617-19 Coden: MOCMB7; ISSN: 0026-9247, 1986, 1986.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Puniyani, Sushil et al.: “Platinum (II) complexes of cyclohexanone and cyclopentanone thiosemicarbazones” XP002317071 retrieved from STN Database accession No. 1985:447222 abstract & Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 24a(3), 240-1 Coden: IJCADU; ISSN: 0376-4710, 1985.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Syamal, A. et al.: “Synthesis of new platinum (II) complexes with ethanethiolamine, o-aminothiophenol and bidentate carboxylic acids” XP002317072 retrieved from STN Database accession No. 1983: 209058 abstract & Revue De Chimie Minerale, 20(1), 123-8 Coden: RVCMA8; ISSN: 0035-1032, 1983.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Uttecht, j.-g. et al.: Synthesis, vibrational spectra and normal coordinate analysis of (n-Bu4N)2 ′Pt(SCN)n(ox), n-2, 4, and crystal structure of ′(C5H5N)2CH2 ′Pt(SCN)4(ox) XP002317073 retrieved from STN Database accession No.
Gonzalez P. Nazario
Morrison & Foerster / LLP
Platco Technologies (Proprietary) Limited
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