Platinum(II) complexes of N-substituted amino dicarboxylates...

Details Platinum(II) complexes of N-substituted amino dicarboxylates... Platinum(II) complexes of N-substituted amino dicarboxylates...

2005-03-15

2005-03-15

Nazario-Gonzalez, Porfirio (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C514S492000

Reexamination Certificate

active

06867316

ABSTRACT:
Disclosed are a platinum (II) complex of N-substituted amino dicarboxylate showing antitumor activity represented by the following formula (1) and a preparation method thereof:wherein n is 1 or 2; A—A is a diamine selected from the group consisting of trans-(±)-1,2-diaminocyclohexane, ethylenediamine and 2,2-dimethyl-1,3-propanediamine; and R1is hydrogen and R2is RCO or RSO2, wherein R is an alkyl selected from the group consisting of methyl, ethyl, n-propyl, n-butyl and t-butyl or an aryl selected from the group consisting of phenyl and substituted phenyl group, or R1R2is phthaloyl.

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