Platinum(II) complex and processes for preparing the same

Details Platinum(II) complex and processes for preparing the same Platinum(II) complex and processes for preparing the same

1993-09-14

1995-03-07

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549450, 549451, 556137, C07F 1500, C07D31700

Patent

active

053959477

ABSTRACT:
Disclosed herein are novel platinum(II) complexes having a potent anti-tumor activity which are represented by the formula (1), ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are a hydrogen atom or a C.sub.1-4 alkyl group, respectively, or jointly form a cycloalkane group together with the carbon atom attached thereto; two Xs jointly form a group represented by formula (a) or (b) wherein, R.sub.3 is a hydrogen atom or a methyl group; R.sub.4 and R.sub.5, which may be the same or different, are a hydrogen atom or a C.sub.1-4 alkyl group, respectively, or jointly form a cyclobutane together with the carbon thereto; and the absolute configurations at the respective chiral centers in the 4,5-bis(aminomethyl)-1,3-dioxolane moiety are (4R,5R) or (4S,5S); processes for the preparing the same; and their use for treating animal or human cancer. Further, disclosed herein are novel intermediates useful for the preparation of the platinum(II) complexes and processes for preparing said intermediates.

REFERENCES:
patent: 4665210 (1987-05-01), Bitha et al.
patent: 4730069 (1988-03-01), Kolar et al.
patent: 4783452 (1988-11-01), Haines et al.
patent: 4870070 (1989-09-01), Bitha et al.
Rosenberg et al., Nature 222, 385, 1969.
Peter W. Feit et al., J. Med. Chem. 7, 14, 1964.
Cancer Chemotheraphy Reports, Part 3, 3(2), 7, 1972.

Affiliated with

Also associated with

Rating

Platinum(II) complex and processes for preparing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Platinum(II) complex and processes for preparing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platinum(II) complex and processes for preparing the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1407070