Platinum-dioxopyrimidine complexes

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424180, 536 23, 536 29, 544225, A61K 31505

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active

044193513

ABSTRACT:
A platinum-[2,4-dioxopyrimidine] complex and pharmaceutical composition suitable as an anti-tumor, anti-bacterial and anti-viral agent and process for the manufacture thereof comprising reacting a 2,4-dioxopyrimidine having the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are suitable substituents with cis-diaquodiamineplatinum (II).

REFERENCES:
Cleare et al., Coordination Chemistry Reviews, vol. 12, pp. 349 and 399-405, Jun. 1974.
Rosenberg, Die Naturwissenschaften, vol. 69, pp. 399-406 (1973).
Connors et al., Platinum Coordin. Complexes in Cancer Chemother., title pp. IX, 40-41, 51, 61 and 66 (1974).
Gelfman et al., Russian J. of Inorganic Chemistry, vol. 5, pp. 16-2-1604 (1970).
Mansy et al., J. Am. Chem. Soc. vol. 95, pp. 1633-1646 (1973).

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