Platinum-diamine complexes, a method for the preparation of a me

Details Platinum-diamine complexes, a method for the preparation of a me Platinum-diamine complexes, a method for the preparation of a me

1981-07-27

1983-10-18

Sneed, Helen M. S.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

260429R, C07F 1500, A61K 3128

Patent

active

044105444

ABSTRACT:
This invention relates to novel platinum-diamine complexes having the formula: ##STR1## wherein R.sub.1 and R.sub.2 independently of each other may be selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, a cycloalkyl group having from 3-7 carbon atoms in the ring, an aralkyl group, and an aryl group having 1-20 carbon atoms, whereas R.sub.1 and R.sub.2 together may form a cycloalkyl group having 3-7 carbon atoms in the ring and having the formula: ##STR2## wherein N is 2 to 7 and wherein R.sub.3 and R.sub.4 independently of each other are selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, an aryl group or an aralkyl group having 1-20 carbon atoms in the alkyl group and X is an anionic group, providing that when X is either chlorine or malonate, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not each H; when X is chlorine and R.sub.1 and R.sub.2 are each H, R.sub.3 and R.sub.4 are not each methyl; when X is chlorine and R.sub.1 and R.sub.2 are each methyl, R.sub.3 and R.sub.4 are not each H, and when X is chlorine R.sub.1 is hydrogen and R.sub.2 is methyl and R.sub.3 and R.sub.4 are not each hydrogen.

REFERENCES:
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patent: 3904663 (1975-09-01), Tobe et al.
patent: 4140707 (1979-02-01), Cleare et al.
Appleton, T. G.; Hall, J. R., Inorganic Chemistry, vol. 11, No. 1, p. 112, 1972.
Appleton, T. G., Hall, J. R., Inorganic Chemistry, vol. 9, No. 8, p. 1800, 1970.
Chemical Abstracts, vol. 80, p. 4, ref. 66593d.
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Chemical Abstracts, vol. 78, 1973, p. 10, ref. 105899p.
Bioinorg. Chem. 2, 187-210, (1973).
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Cleare, M. J. and Hoeschele, J. D., Platinum Metals Rev. 17, (1), 1973.

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