Platinum containing pullulan derivatives and pharmaceutical comp

Details Platinum containing pullulan derivatives and pharmaceutical comp Platinum containing pullulan derivatives and pharmaceutical comp

1988-12-05

1992-03-31

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514908, 536121, 536122, 536124, 556137, A61K 31715, C07M 2300

Patent

active

051008777

ABSTRACT:
A pullulan derivative having one or more active sites resulting from introduction of sulfuric acid, phosphoric acid, a sulfonic acid or a carboxylic acid, wherein one hydrogen atom of the group of the formula ##STR1## occurring at said active sites is partly substituted by a group of the general formula ##STR2## wherein L.sup.1 and L.sup.2 each independently is amine or a unidentate ligand amine or combinedly represent a bidentate ligand amine and Y is an anionic ligand, and/or two hydrogen atoms of the group ##STR3## groups bound to one and the same carbon atom or to two neighboring carbon atoms as occurring at said active sites are, each independently, partly substituted by a group of the general formula ##STR4## wherein L.sup.1 and L.sup.2 are as defined above, and a pharmacologically acceptable salt thereof.
The above compound has anticancer activity and is useful as anticancer agents.
The present invention is concerned with said compound, a process for producing the same and a pharmaceutical use thereof.

REFERENCES:
patent: 4767874 (1988-08-01), Shima et al.
patent: 4948784 (1990-08-01), Mori et al.
Chemical Abstracts, vol. 90, 1979, p. 46, abstract No. 48459s, Columbus Ohio, U.S.; E. Heinen et al.
Chemical Abstracts, vol. 77, No. 13, 25th Sep. 1972, p. 1, abstract No. 83330w, Columbus, Ohio, U.S.; A. J. Thomson et al.

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