Platinum-containing compounds methods for their preparation and

Details Platinum-containing compounds methods for their preparation and Platinum-containing compounds methods for their preparation and

1998-08-10

2000-10-17

Elliott, George C.

Chemistry: analytical and immunological testing

Metal or metal containing

Mn, te, re, fe, ru, os, co, rh, ir, ni, pd, pt

436501, 556136, 536 243, G01N 3320, G01N 33566, C07F 1500, C07H 2104

Patent

active

061330388

ABSTRACT:
The invention provides platinum-based probe compounds having the structure: ##STR1## wherein: Pt is a platinum atom, PROBE is a probe biomolecule for associating to a target biomolecule, M is a detectable marker moiety, and X and Y are stabilizing substituents. Also provided are platinum-based labeling compounds having the structure: ##STR2## wherein: Pt is a platinum atom, M is a detectable marker moiety, A is a displaceable leaving group, and X and Y are stabilizing substituents. The invention further provides platinum-based linker compounds having the structure: ##STR3## wherein: Pt is a platinum atom, A and B are the same or different reactive moieties, and X and Y are stabilizing substituents. Other Pt.sup.II and Pt.sup.IV compounds are also provided. Moreover, the invention provides methods for the preparation and use of these compounds, as well as diagnostic kits which contain the compounds.

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