Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1988-01-14
1990-09-11
Griffin, Ronald W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 187, 536 22, 536 55, 536122, 536 552, 514 23, 424649, A61K 3128, A61K 3170, C07H 2300
Patent
active
049564595
ABSTRACT:
Compounds of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is independently selected from the group consisting of halogen, hydroxy, or mono carboxylic acid or R.sub.1 and R.sub.2 together is a multifunctional carboxylic acid residue which forms a ring with the platinum atom through two oxygens of said multifunctional carboxylic acid; R.sub.3 is a deoxy mono or disaccharide or a derivative thereof; and R.sub.4 is selected from the group consisting of hydrogen, C.sub.1-4 -alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl, wherein substituents are selected from the group consisting of halogen, nitro, C.sub.1-2 -alkoxy, carboxy, carbony ester or phenyl or a pharmaceutically acceptable salt thereof are disclosed. Compositions containing these compounds and methods using these compounds are also discussed.
REFERENCES:
patent: 4053587 (1977-10-01), Davidson et al.
patent: 4200583 (1980-04-01), Kidani et al.
patent: 4284579 (1981-08-01), Meischen et al.
patent: 4536571 (1985-08-01), Stockel et al.
patent: 4551524 (1985-11-01), Kidani
patent: 4571335 (1986-02-01), Taylor et al.
patent: 4575550 (1986-03-01), Totani
patent: 4587331 (1986-05-01), Hlavka et al.
patent: 4673754 (1987-06-01), Smith et al.
patent: 4696918 (1987-09-01), Stoddart et al.
patent: 4703115 (1987-10-01), Hlavka et al.
patent: 4786725 (1988-11-01), Amundsen et al.
O. Gandolfi et al., "Aminomalonato(1,2-Diaminocyclohexane)Platinum(II)," Inorganica Chimica Acta, vol. 135, pp. 27-31, 1987.
M. P. Hacker et al., "Water-soluble N-Substituted Iminodiacetato(1,2-Diaminocyclohexane)-Platinum (II) Complexes as Potential Antitumor Agents," Cancer Research, vol. 46, pp. 6250-6254, 1986.
L. A. Zwelling, "Cisplatin and New Platinum Analogs," Cancer Chemotherapy 7, Ch. 8, pp. 105-122, 1985.
Gandolfi et al.; Inorganica Chimica Acta, 80:103-106, (1983).
Tobe et al.; Journal of Clinical Hematology and Oncology, 7(1):114-137, (1977).
Thiel et al.; Chemical Abstracts, 100:44337c, (1984).
Nagel et al.; Chemical Abstracts, 105:79243z, (1986).
Tsubomura et al.; Chemical Abstracts, 105:191536y, (1986).
Kolar et al.; Chemical Abstracts, 105:209336v, (1986).
Green Dianna C.
Hammer Charles F.
Schein Philip S.
Talebian Abdolhossen
Carson Nancy S.
Georgetown University
Griffin Ronald W.
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