Platinum complexes with one radiosensitizing ligand

Details Platinum complexes with one radiosensitizing ligand Platinum complexes with one radiosensitizing ligand

1987-04-13

1990-05-01

Lieberman, Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 64, 546 11, 546110, 546112, C07F 1702

Patent

active

049219634

ABSTRACT:
Complexes of platinum II containing a single radiosensitizer ligand and an amino or ammine substituent shows superior binding to DNA and are useful in chemotherapy and sensitization of hypoxic tumors to radiation. The chemotherapeutic value of these compounds is enhanced by administration of vasoactive agents.

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