Platinum complexes with mononitrile-containing ligands

Details Platinum complexes with mononitrile-containing ligands Platinum complexes with mononitrile-containing ligands

2006-04-17

2009-08-04

Gonzalez, Porfirio Nazario (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

C514S359000, C546S002000, C548S101000, C556S137000

Reexamination Certificate

active

07569606

ABSTRACT:
Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i.e., L1and L2)which can be hydrolyzed iii vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.

REFERENCES:
Kharitonov et al., Doklady Akademii Nauk SSSR, vol. 141, pp. 645-648 (1961).
Uchiyama, et al., The Isolation, “Characterization, and Isomerization of cis- and trans-Bis(benzonitrile)dichloroplatinum(II)”, Bull. Chem. Soc. Jpn., 54:181-85 (1981).

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