Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Reexamination Certificate
2007-07-03
2007-07-03
Nazario-Gonzalez, Porfirio (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
C546S002000, C548S101000, C514S359000, C514S492000
Reexamination Certificate
active
11340048
ABSTRACT:
Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i.e., L1and L2) which can be hydrolyzed in vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.
REFERENCES:
patent: 5107007 (1992-04-01), Farrell
patent: 2002/0165369 (2002-11-01), Braman et al.
patent: 2004/0039051 (2004-02-01), Shaw
Kharitonov et al., Doklady Akademii Nauk SSSR, vol. 141, pp. 645-648 (1961).
Uchiyama, et al., The Isolation, “Characterization, and Isomerization of cis- and trans-Bis(benzonitrile)dichloroplatinum(II)”, Bull. Chem. Soc. Jpn., 54:181-85 (1981).
Hausheer Frederick H.
Petluru Pavankumar
Xiao Zejun
BioNumerik Pharmaceuticals, Inc.
Whitaker Scott A.
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