Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Patent
1994-01-07
1995-06-20
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
C07F 1500
Patent
active
054262038
ABSTRACT:
Novel platinum complexes wherein malonate derivative is the anion ligand are provided with processes for preparation thereof. The complexes of the present invention have excellent antitumor effect and low toxicity.
REFERENCES:
patent: 5142075 (1992-08-01), Sohn et al.
Nature, Feb. 13, 1965, vol. 205, pp. 698-699, by B. Rosenberg, entitled "Inhibition of Cell Division in Escherichia Cell by Electrolysis Products from a Platinum Electrode".
Biochimie, 1978, vol. 60, pp. 825-850, by M. J. Cleare, entitled "Anti-Tumor Platinum Compexes: Relationships Between Chemical Properties and Activity".
Inorganic Chimica Acta, vol. 46, 1980, pp. L15-L16, by R. C. Harrison and C. A. McAuliffe, entitled "An Efficient Route for the Preparation of Highly Soluble Platinum (II) Antitumor Agents".
Can. J. Chem., vol. 64, 1894, (Revised 1986) pp. 1894-1896, by F. D. Rochon and P. C. Kong, entitled "Iodo-Bridged Complexes of Platinum(II) and Synthesis of cis Mixed-Amine Platinum (II) Compounds".
Telbahedron, vol. 29, (1973) pp. 635-638, by W. Lehnert, entitled: "Knoevenagel-Kondensationen mit TiCl.sub.1 /BASE--III.sup.1 ".
European Journal, Cancer, vol. 7, (1981) pp. 129-141 by Abraham Goldin et al, entitled: "Current Results of the Screening Program at the Division of Cancer Treatment, National Cancer Institute".
Jung Ok S.
Kim Kwan M.
Lee Young A.
Sohn Youn S.
Dees Jos,e G.
Korea Institute of Science and Technology
Nazario-Gonzalez Porfirio
LandOfFree
Platinum complexes of malonic acid derivatives and process for t does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Platinum complexes of malonic acid derivatives and process for t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platinum complexes of malonic acid derivatives and process for t will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1845153