Platinum complexes of azodiazonium dyes as anti-tumor agents

Details Platinum complexes of azodiazonium dyes as anti-tumor agents Platinum complexes of azodiazonium dyes as anti-tumor agents

1989-03-13

1991-01-15

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Acyclic nitrogen double bonded to acyclic nitrogen, acyclic...

534562, C07C24520, A61K 31655

Patent

active

049854160

ABSTRACT:
Complexes having the structure ##STR1## in which R, R.sub.1, R.sub.2, R.sub.3 represent lower alkyl groups are cytotoxic to tumor cells in mammals and enhance the killing effect of radiation and heat.

REFERENCES:
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Teicher et al. I, Int. J. Rad. Onc. Biol. Phys., vol. 11, 937-941, (1985).
Teicher et al. II, Int. J. Rad. Onc. Biol. Phys., vol. 13, 1217-1224, (1987).
Teicher et al. III, Rad. Res., vol. 109, 58-67, (1987).
Teicher et al. IV, Biochem. Pharmacol., vol. 35, 3365-3369, (1986).

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