Platinum complexes as antitumor agents

Details Platinum complexes as antitumor agents Platinum complexes as antitumor agents

2005-05-17

2005-05-17

Ford, John M. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S225000, C514S365000, C514S374000, C514S378000, C514S406000, C548S146000, C548S356100, C548S215000, C548S240000

Reexamination Certificate

active

06894049

ABSTRACT:
The present invention relates to platinum antitumor drugs. In particular, it relates to platinum complexes having formula Ia or Ibor a pharmaceutically acceptable salt thereofwherein:each A is independently an anion;each B is independently halo, hydroxy, carboxylate, carbamate or a carbonate ester,Z is a substituted 5- or 6-membered, heterocyclic moiety wherein at least one substituent sterically hinders access of the Pt atom to a DNA strand of a tumor cell, and wherein Z is other than pyridine; andX is NH3or mono- or dialkyl substituted NH3.which are active against cancer cells and have improved aqueous solubility and activity.

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