Platinum complexes and antitumor agents containing them as an ac

Details Platinum complexes and antitumor agents containing them as an ac Platinum complexes and antitumor agents containing them as an ac

1990-03-16

1990-11-06

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

556136, 549211, 549212, C07F 1500

Patent

active

049688260

ABSTRACT:
Novel platinum complexes of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each identically of differently is lower alkyl, or R.sup.1 and R.sup.2 taken together form --(CH.sub.2)m--, and m is an integer from 2 to 5, and antitumor agents comprising the compound (I), which are effective against cisplatin-resistant ascitic murine leukemia, murine leukemia, and solid tumor, with slight hemotoxicity and nephrotoxicity.

REFERENCES:
patent: 4760156 (1988-07-01), Heffernan et al.
patent: 4808730 (1989-02-01), Bitha et al.

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