Platinum complexes

Details Platinum complexes Platinum complexes

1991-04-19

1992-07-14

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

556136, C07F 1500

Patent

active

051304503

ABSTRACT:
A platinum (II) complex represented by the general formula: ##STR1## [wherein A's are each ammonia or two A's jointly represent 1,2-diaminocyclohexane, 1-amino-1-aminomethylcyclohexane or 1,4-diamino-2-methylbutane; and B's may be same or different and represent ##STR2## (wherein m is 0, 1 or 2; n is 0 or 1; R.sub.1 is a C.sub.3 -C.sub.6 alkyl group substituted with one or two hydroxyl groups) or two B's jointly represent ##STR3## (wherein R.sub.2 is a C.sub.2 -C.sub.5 alkyl group substituted with one hydroxyl group)].
These platinum (II) complexes have high potencies for use as an antitumor agent.

REFERENCES:
patent: 4271085 (1981-06-01), Amundsen et al.
patent: 4482569 (1984-11-01), Bulten et al.
patent: 4505928 (1985-03-01), Amundsen et al.
patent: 4710577 (1987-12-01), Kidani et al.
patent: 4748254 (1988-05-01), Cheltsov-Bebutov et al.
patent: 4760157 (1988-07-01), Child et al.
patent: 4968826 (1990-11-01), Totani et al.
The Journal of Clinical Hematology and Oncology, vol. 7, No. 3, 1977, pp. 856-857.

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