Platinum complex

Details Platinum complex Platinum complex

1988-09-16

1990-02-27

Doll, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C07F 1500

Patent

active

049048090

ABSTRACT:
A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituent, or in combination represent a group: ##STR2## wherein R.sub.1 and R.sub.2 independently represent a hydrogen atom, a hydroxyl group, or a lower alkyl group, or in combination with each other and with the adjacent carbon atom a cyclobutane ring, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a sulfo group, or nitro group.

REFERENCES:
patent: 4500465 (1985-02-01), Amundsen et al.
CHEMICO--BIOLOGICAL INTERACTIONS, vol. 46, No. 2, 1983, pp. 219-232, Elsevier Scientific Publishers Ireland Ltd., GB; B. Das SARMA et al.: "Platinum Complexes with Anticancer Potential and Their Evaluation by a Colorimetric Lambda Prophage Induction Assay", *p. 222, compound 24*.
Appleton, T. G. and Hall, J. R. in Inorganic Chemistry, vol. 11, No. 1, 1972, pp. 112-117.

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