Platinum carboxylate anticancer compounds

Details Platinum carboxylate anticancer compounds Platinum carboxylate anticancer compounds

2006-10-31

2006-10-31

Nazario-Gonzalez, Porfirio (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C514S492000

Reexamination Certificate

active

07129368

ABSTRACT:
Platinum carboxylate anticancer compounds, pharmaceutical compositions that include the platinum carboxylate compounds, and methods for treating cellular proliferative diseases by administering the platinum carboxylate compounds.

REFERENCES:
patent: 4140707 (1979-02-01), Cleare et al.
patent: 4177263 (1979-12-01), Rosenberg et al.
patent: 4533502 (1985-08-01), Rochon et al.
patent: 4704464 (1987-11-01), Brunner et al.
patent: 5117022 (1992-05-01), Khokhar et al.
patent: 5648384 (1997-07-01), Kidani et al.
patent: 5922689 (1999-07-01), Shaw
patent: 6001817 (1999-12-01), Shaw
patent: 6011166 (2000-01-01), Valsecchi et al.
patent: 6130345 (2000-10-01), Doppelt
patent: 6194403 (2001-02-01), Hu et al.
patent: 6297245 (2001-10-01), Shaw
patent: 6331559 (2001-12-01), Bingham et al.
patent: 898 614 (1984-05-01), None
patent: 2 019 397 (1979-10-01), None
patent: 2 137 198 (1984-10-01), None
patent: WO 96/16068 (1996-05-01), None
patent: WO 00/63219 (2000-10-01), None
Kortes et al., Crystal and Molecular Structure of a Potentail DNA Groove-Spanning Chelate: [MV][Pt2(hdta)C12].4H20 (MV2+= 1,1′-Dimethyl-4,4′-bipyridinium, hdta4-=1,6-Hexanediamine-N,N,N′,N′-tetraacetate), Inorganic Chemistry, vol. 38, No. 22, pp. 5045-5052 (1999).
Brunner, H., et al., “Porphyrin Platinum Conjugates—New Aims,”Inorganica Chimica Acta 357:1649-1669, 2004.
Craciunescu, D., and A.D. Lopez, “Relation Between Structure and Antineoplastic Activity of New Cis-PtII(L)2(X) and PtIV(L)2(OH)2(X) Complexes, Where L-Cyclohexylamine and X2-Is the Dianion of an Organic Acid,”Anales De La Real Academia De Farmacia 50(3):389-403, 1984.
Rochon, F.D., and P.-C. Kong, “Antitumor Evaluation of Some New Platinum Compounds,”Journal of Cinical Hematology and Oncology 12(2):39-43, 1982.
Appleton, T.G., et al., “Amino Acid Complexes of Platinum(IV). VI. Ethylenediamine-tetraacetate (EDTA) Complexes,”Inorgica Chimica Acta, 61:51-56, 1982.
Charalabopoulos, K., et al., “Antitumour and Toxic Effects on Wistar Rats of Two New Platinum Complexes,”European J. of Clin. Invest.32:129-133, 2002.
Criado, J.J., “Synthesis and Characterization of Sodiumcis-dichlorochenodeoxycholylglycinato(O,N) Platinum(II)—Cytostatic Activity,”BioMetals 12:281-288, 1999.
Fan, D., et al., “Antitumor Activity Against Human Tumor Samples ofcis-Diamminedichloroplatinum(II) and Analogues of Equivalentin VitroMyelotoxic Concentrations,”Cancer Research 48:3135-3139, Jun. 1, 1988.
Galanski, M., “The Mode of Action of Antitumor Platinum Compounds Linked to Amino Phosphonic Acids With Particular Activity Against Bone Malignancies and the Influence of Calcium Ions Onto the DNA Binding Behavior,”Contrib Oncol. 54:435-438, 1999.
Han, I., et al., “Enhanced Antitumor Activity oftrans(±)-1,2-Diaminocyclo-hexaneglutamatoplatinum(II) Formulated With Stealth Liposome,”Biorgan&Medicinal Chem 11:5443-5447, 2003.
Herrera, M.C., et al., “Comparison of the Effects of Bischolylglycinatechloro-Platinum(II) Versus Cisplatin on Liver Regeneration After Partial Hepatectomy,”Anticancer Res. 18:3555-3564, 1998.
Jolley, J.N., et al., “Synthesis and Antitumour Activity of Platinum (II) and Platinum (IV) Complexes and Containing Ethylenediamine-Derived Ligands Having Alcohol, Carboxylic Acid and Acetate Substituents. Crystal and Molecular Structure of [PtL4Cl2] H2O where L4is Ethylenediamine-N,N'-Diacetate,”J. Inorg. Biochem. 83:91-100, 2001.
Kortes, R.A., “Crystal and Molecular Structure of a Potential DNA Grove-Spanning Chelate: [MV][Pt2(hdta) Cl2] 4H2O (MV2+=1, 1′-Dimethyl-4-4′-bipyridinium, hdta4−=1,6-Hexanediamine-N,N,N′N′-tetraacetate),”Inorg. Chem. 38(22):5045-5052, Oct. 2, 1999.
Lautersztain, J., et al., “Antitumor Activity of LiposomalCis-BisN-Decyl-Iminodiacetato-1, 1-Diaminocyclohexane-Platinum (II) Against L1210 Leukemia and Metastases of M5076 Murine Reticulosarcoma,”J. Liposome Res. 1(1):1-13, 1988-89.
Lin, F.-T., et al., “Substitution of Inosine for Chloride in [Pt2(hdta)Cl2]2-(hdta4−=1,6-hexanediamine-N,N,N′,N′-tetraacetate),”Inorganica Chimica Acta 2:124-128, 1998.
Offiong, O.E., et al., “Synthesis, Spectral and Cytotoxicity Studies of Palladium(II) and Platinum(II) Amino Acid Schiff Base Complexes,”Trans. Metal. Chem. 25:369-373, 2000.
Sandman, K.E., et al., “A Mechanism-Based, Solution-Phase Method for Screening Combinatorial Mixtures of Potential Platinum Anticancer Drugs,”JBIC 3:74-80, 1998.
Sep. 17, 2003 Abstract, Derwent Publications Ltd., London, GB.
Akerley, W., et al., “Weekly, High-Dose Paclitaxel in Advanced Lung Carcinoma,”Cancer 97(10):2480-2486, May 15, 2003.
Baumgartner, M.R., et al. “The Interaction of Transition Metals With the Coenzyme α-Lipoic Acid: Synthesis, Structure and Characterization of Copper and Zinc Complexes,”Inorganica Chimica Acta 252:319-331, Nov. 1996.
Farrell, N., “Polynuclear Charged Platinum Compounds as a New Class of Anticancer Agents,” in L.R. Kelland and N. Farrell (eds.),Platinum-Based Drugs in Cancer Therapy, Humana Press Inc., Totowa, New Jersey, Jun. 2000, pp. 321-339.
Fuertes, M.A., et al., “Novel Concepts in the Development of Platinum Antitumor Drugs,”Curr. Med. Chem.—Anti-Cancer Agents 2(4):539-551, 2002.
Hegmans A., et al., “Novel Approaches to Polynuclear Platinum Pro-Drugs. Selective Release of Cytotoxic Platinum-Spermidine Species Through Hydrolytic Cleavage of Carbamates,”Inorg. Chem. 40(24):6108-6114, Oct. 20, 2001.
Leonetti, C., et al., “α-Tocopherol Protects Against Cisplatin-Induced Toxicity Without Interfering With Antitumor Efficacy,”Int. J. Cancer 104(2):243,250, 2003.
Manzotti, C., et al., “BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin,”Clinical Cancer Res. 6:2626-2634, Jul. 2000.
Martin-Ramos, J.D., et al., “Copper(II) and Nickel(II) Chelated With Dihydrogen Trans-1,2-Diaminocyclohexane-N,N,N′N′-Tetraacetate(2-) Ion (H2CDTA2−). Synthesis, XRD Structure and Properties of [Cu(H2CDTA)] H2O and [Ni(H2CDTA)(H2O)] 4H2O”,Polyhedron 15(3)439-446, 1996.
Pace, A., et al., “Neuroprotective Effect of Vitamin E Supplementation in Patients Treated With Cisplatin Chemotherapy,”J. Clin. Oncol. 21(5):927-391 Mar. 2003.
Qu, Y., et al., “Synthesis, Characterization, and Cytotoxicity of Trifunctional Dinuclear Platinum Complexes: Comparison of Effects of Geometry and Polyfunctionality on Biological Activity,”J. Med. Chem. 43(16):3189-3192, Jul. 20, 2000.
Serimaa, R., et al., “X-Ray Scattering Study on Amorphous, Polynuclear Platinum Uridine Complexes,”J. Am. Chem. Soc 115(22):10036-10041, Nov. 3, 1993.

Affiliated with

Also associated with

Rating

Platinum carboxylate anticancer compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Platinum carboxylate anticancer compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platinum carboxylate anticancer compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3666295