Platinum and palladium complexes

Details Platinum and palladium complexes Platinum and palladium complexes

1983-10-14

1986-04-22

Sneed, Helen M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

514492, 536112, 536121, C07F 1500

Patent

active

045843929

ABSTRACT:
Compositions of matter are provided wherein cis-platinum (II) and cis-palladium (II) moieties having amine substituents are bonded to anionic macromolecular entities. These compositions of matter may have improved solubility in the plasma and are effective antitrypanosomal and antitumor agents in mammals. Alternatively, the compositions of matter may be insoluble in water and particularly adapted for in situ implantation into tumerous masses.

REFERENCES:
patent: 4140707 (1979-02-01), Cleare et al.
patent: 4372890 (1983-02-01), Yoshikumi et al.
patent: 4376782 (1983-03-01), Turkevich et al.
Chemical Abstracts, 77, 19198g (1972).
Chemical Abstracts, 79, 140094q (1973).
Chemical Abstracts, 86, 106009a (1977).
Chemical Abstracts, 88, 90508r (1978) & 88, 21429d (1978).
Chemical Abstracts, 78, 44295q (1973).
Chemical Abstracts, 94, 80456g (1981).
Chemical Abstracts, 80, 122031h (1974).
Chemical Abstracts, 95, 199664j (1981).
Morris et al., Chemico-Biological Interactions, 7(5), pp. 305-315 (1973).
Connors et al., Chem.-Biol. Interactions, 5, pp. 418-420 (1972).
Chemical Abstracts, 80, 9949(a) (1974).
Chemical Abstracts, 77, 159606p (1972).
Chemical Abstracts, 69, 40854n (1968).
Chemical Abstracts, 80, 32040f (1974).

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