Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Patent
1990-02-07
1991-07-02
Prescott, Arthur C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
556136, 556 40, 514492, 514188, 546 2, C07F 1500, A61K 3300
Patent
active
050287265
ABSTRACT:
Platinum amine sulfoxide complexes of the formula [PtCl(diam)(R.sub.2 SO)].sup.+ X.sup.- wherein diam represents a bidentate amine, R is C.sub.3 -C.sub.7 alkyl or cycloalkyl and X.sup.- is an anion, exhibit favorable anti-tumor activity in vivo against tumors susceptible to therapy with platinum.
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Boucher, Heather and B. Bosnich, "Asymmetric Synthesis. Interligand Chiral Recognition between Prochiral Olefins and a Chiral Sulfoxide Coordinated to Platinum (II)", Journal of the American Chemical Society, vol. 99, No. 19 (Sep. 14, 1977), pp. 6253-6261.
Hacker, Miles P. et al. "Ascorbato(1,2-diaminocycloshexane):platinum(II) Complexes, a New Series of Water-soluble Antitumor Drugs", Cancer Research, vol. 45 (Oct. 1985), pp. 4748-4753.
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Prescott Arthur C.
The University of Vermont and State Agricultural College
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