Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-10-17
1999-11-02
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530331, 530362, 530363, 530380, 530402, 530412, 530427, 4241931, 4241941, 424484, 424499, 514 2, 514 18, 514773, 514776, 514832, 514965, A61K 3514, A61K 39385, C07K 1700
Patent
active
059773138
ABSTRACT:
Platelet substitutes, comprising fibrinogen, or analogous products useful in therapy, which further comprise an insoluble carrier to which is bound an essentially non-degraded active protein including the sequence Arg-Gly-Asp. Such conjugates can be made by a conjugation process comprising 0.01 to 2.5% by weight active fibrinogen, and no more that 50% inactive fibrinogen.
REFERENCES:
patent: 5069936 (1991-12-01), Yen
patent: 5308620 (1994-05-01), Yen
patent: 5616311 (1997-04-01), Yen
patent: 5725804 (1998-03-01), Yen
Agam, G. and Livne, A., "Passive Participation of Fixed Platelets in Aggregation Facilitated by Covalently Bound Fibrinogen," Blood 61(1): 186-191 (1983).
Agam, G. and Livne, A., "Platelet-Platelet Recognition During Aggregation: Distinct Mechanisms Determined by the Release Reaction," Thrombosis and Haemostasis 51(2): 145-149 (1984).
Agam, G. and Livne, A., "Resolution and Reconstitution of Interplatelet Recognition During Aggregation," Thrombosis and Haemostasis 59(3): 504-506 (1988).
Agam, G. and Livne, A., "Erythrocytes with covalently bound fibrinogen as a cellular replacement for the treatment of thrombocytopenia," Euro. J. Clin. Invest. 22:105-112 (1992).
Coller, B. S., "Interaction of Normal, Thrombasthenic, and Bernard-Soulier Platelets With Immobilized Fibrinogen: Defective Platelet-Fibrinogen Interaction in Thrombasthenia," Blood 52(2): 169-178 (1980).
Coller, B. S. et al., "Thromboerythrocytes," J. Clin. Invest. 89:546-555 (1992).
Dardik, R. et al., "Platelets Mediate Tumor Cell Adhesion to the Subendothelium Under Flow Conditions: Involvement of Platelet GPIIb-IIIa and Tumor Cell .alpha..sub.v Integrins," Int. J. Cancer 70:201-207 (1997).
Yen, R. C. K. et al., "A New Hemostatic Agent: Thrombospheres Shorten the Bleeding Time (BT) in Thrombocytopenic Rabbits," XVth Congress of the International Society on Thrombosis and Haemostasis, Jerusalem, Israel, Jun. 11-16, 1995 (Abstract).
D'Souza et al, The Journal of Biological Chemistry, vol. 263, No. 8 pp. 3943-3951, Mar. 15, 1988.
Church Nicola Jane
Harris Roy
Heath David
Middleton Sarah Margaret
Mohamed Abdel A.
Quadrant Healthcare Limited
Tsang Cecilia J.
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