Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-04-17
2000-02-08
Prouty, Rebecca E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530300, 530350, 530380, 435215, 514 2, 424 9463, C07K 1900, A61K 3817
Patent
active
060228547
ABSTRACT:
A therapeutic compound comprises a KGD-containing peptide, tandem repeats thereof, combinations thereof, or combinations thereof with an RGD-containing peptide or tandem repeats thereof, or peptide analogues or non-peptide organic analogues of the RGD and KGD tripeptides, and a pharmaceutical agent. A therapeutic composition comprises the compound of this invention and a pharmaceutically acceptable carrier. A polydeoxyribonucleotide comprises a DNA sequence, and a polyribonucleotide comprises an RNA sequence, encoding the compound of the invention, where the pharmaceutical agent is a peptide. A self-replicating DNA carries the polydeoxyribonucleotide described above and a transformed host cell comprises the self-replicating DNA. Therapeutic platelets are loaded with a therapeutic compound comprising a peptide comprising RGD or KGD, peptide analogues or organic analogues thereof, tandem repeats thereof, or combinations thereof, and a pharmaceutical agent operatively linked to the peptide. A method of delivering a pharmaceutical agent to a site afflicted with a disease comprises administering an effective amount of the therapeutic platelets or the therapeutic compound comprising RGD or KGD and a pharmaceutical agent. When the method is applied to preventing or countering vascular thrombosis or atherosclerosis, the pharmaceutical agent comprises an anti-thrombotic or an anti-atherosclerotic agent or active fragments thereof, respectively, and the peptide comprises an RGD or KGD peptide or, peptide analogues or organic analogues thereof, combinations thereof.
REFERENCES:
patent: 5242810 (1993-09-01), Maraganore et al.
A. Knapp et al. "Hirudisins" J. Biol. Chem. 267(34) 24230-24234 (Dec. 1992).
C. Bode et al. "Platelet Targeted Fibrinolysis Enhances Clot Lysis and Inhibits Platelet Aggregation" Circulation 84(2) 805-813 1991 (See Embase Abstract).
F.C. Church et al. "Chimeric Antithrombin Peptide." J. Biol Chem. 266(18) 11975-11979 (Jun. 25, 1991).
R.M. Scarborough et al. "Barbourin" J. Biol. Chem. 266(15) 9359-9362 (May 25, 1991).
Prouty Rebecca E.
The Regents of the University of California
Verny Hana
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