Platelet related growth regulator

Details Platelet related growth regulator Platelet related growth regulator

1985-03-15

1987-02-24

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, C07K 710

Patent

active

046458280

ABSTRACT:
Novel polypeptide compositions are provided which inhibit human tumor cell growth, which may or may not stimulate autophosphorylation of pp60 src and induce the release of a 52 kDal polypeptide from neoplastic cells. Individual polypeptides may be isolated from mammalian blood platelets by selected extraction and purification procedures, may be synthesized or produced by hybrid DNA technology.

REFERENCES:
Morgan et al., Thrombos. Haemostas. (Stuttg.), 1979, 42:1652-1660.
Dawes et al., Thrombosis Research, 1983, 29:569-581.
Lawler, Thrombosis Research, 1981, 21:121-127.

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