Platelet receptor antagonists useful in detecting intravascular

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 145, 424 165, A61K 4902

Patent

active

053343697

ABSTRACT:
This invention provides novel compounds used in a method of determining platelet deposition. These compounds include .sup.123 I-SAP and analogues. Also provided is a method of determining platelet deposition in a subject comprising binding an effective radiolabeled platelet receptor antagonist with a platelet, allowing sufficient time for the platelet to migrate within the subject, and visualizing the radiolabeled platelet in the subject.

REFERENCES:
patent: 4276280 (1981-06-01), Akerkar et al.
patent: 4520112 (1985-05-01), Snyder et al.
patent: 4619823 (1986-10-01), Yokoyama et al.
patent: 4656280 (1987-04-01), Garlick
patent: 4783330 (1988-11-01), Furie et al.
patent: 4976891 (1990-12-01), Narisada et al.
patent: 4990326 (1991-02-01), Noujaim et al.
patent: 5002972 (1991-03-01), Narisada et al.
patent: 5008409 (1991-04-01), Narisada et al.
patent: 5026537 (1991-06-01), Daddona et al.
Mais, et al., "Radioiododestannylation. Convenient Synthesis of a High Affinity Thromboxane A.sub.2 /Prostaglandin H.sub.2 Receptor Antagonist," Journal of Labelled Compounds and Radiopharmaceuticals XXIX:75-79, 1991.
Brenner et al., "Platelet Scintigraphy in Cerebrovascular Diseases," Eur Neurol 29:197-201, 1989.
Isaka et al., "Platelet Aggregability and in Vivo Platelet Deposition in Patients with Ischemic Cerebrovascular Disease--Evaluation by Indium-111 Platelet Scintigraphy," Thrombosis Research 56:739-749, 1989.
Farlow et al., "Early Image Acquisition After Administration of Indium-111 Platelets in Clinically Suspected Deep Venous Thrombosis," The American Journal of Cardiology 64:363-368, 1989.
Ushikubi et al., Eicosanoids, vol. 2 (1989) pp. 21-27.
Narisada et al., J. Med. Chem. (1988) vol. 31, pp. 1847-1854.
Narisada et al., J. Org. Chem. (1989) vol. 54, pp. 5308-5313.
Chemical Abstracts, 111(19):168053d (Nov. 6, 1989) Hanasaki et al., Biochem. Pharmacol., 38(18), pp. 2967-2976.
Chemical Abstracts 111(11):91094h (Sep. 11, 1989) Hanasaki et al., Biochem. Pharmacol., 38(12), pp. 2007-2017.
Chemical Abstracts, 114(1):1107z (Jan. 1, 1991) Ushikubi et al., Eicosanoids, 2(1), pp. 21-27.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Platelet receptor antagonists useful in detecting intravascular does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Platelet receptor antagonists useful in detecting intravascular , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platelet receptor antagonists useful in detecting intravascular will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-63754

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.