Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Reexamination Certificate
2011-06-21
2011-06-21
Saucier, Sandra (Department: 1651)
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
Reexamination Certificate
active
07964338
ABSTRACT:
The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.
REFERENCES:
patent: 4455299 (1984-06-01), Grode
patent: 4800016 (1989-01-01), Yang
patent: 5256559 (1993-10-01), Maraganore et al.
patent: 5798238 (1998-08-01), Goodrich, Jr. et al.
patent: 5801063 (1998-09-01), Grandics et al.
patent: 5858238 (1999-01-01), McRea et al.
patent: 5869701 (1999-02-01), Park et al.
patent: 5919614 (1999-07-01), Livesey et al.
patent: 5955256 (1999-09-01), Sowemimo-Coker et al.
patent: 5981163 (1999-11-01), Horowitz et al.
patent: 6030767 (2000-02-01), Wagner et al.
patent: 6087141 (2000-07-01), Margolis-Nunno et al.
patent: 6106773 (2000-08-01), Miekka et al.
patent: 6733471 (2004-05-01), Ericson et al.
patent: 2001/0044584 (2001-11-01), Kensey
Bode et al., “Extended Storage of Platelets in an Artificial Medium with the Platelet Activation Inhibitors Prostaglandin E1 and Theophylline”, Vox Sang. 60 : 105-112 (1991).
Mousa et al. “Antiplatelet and Antithrombotic Efficacy of DMP 728, a Novel Platelet GPIIb/IIIa Receptor Antagonist”, Circulation 89 (1) : 3-12 (1994).
Frietsch et al. “Artificial oxygen carriers”, European Journal of Anesthesiology 15 : 571-584 (1998).
Lowe, “Second-Generation Perfluorocarbon Emulsion Blood Substitutes”, Art. Cells, Blood Subs. and Immob. Biotech. 28 (1) : 25-38 (2000).
Uzan , “Antithrombotic agents”, Chapter 12, Emerging Drugs 3 : 189-208 (1998).
American Heritage Stedman's Medical Dictionary 2002, definition of “cell culture”, accessed Sep. 8, 2008.
Hirsh, J. et al., “New antithrombotic agents”, The Lancet, vol. 353, pp. 1431-1436, Apr. 24, 1999.
Pinto, Donald J.P. et al., “Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa1”, J. Med. Chem., vol. 44, pp. 566-578, (2001).
Pruitt, James R. et al., “Isoxazolines and Isoxazoles as Factor Xa Inhibitors”, Bioorg. Med. Chem. Lett., vol. 10, pp. 685-689, (2000).
Quan, Mimi L. et al., “Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors”, J. Med. Chem., vol. 42, pp. 2752-2759, (1999).
Sato, K. et al., “Relationship between the antithrombotic effect of YM-75466, a novel factor Xa inhibitor, and coagulation parameters in rats”, European Journal of Pharmacology, vol. 347, pp. 231-236, (1998).
Wong, P.C., et al., “Nonpeptide Factor Xa Inhibitors: I. Studies with SF303 and SK549, a New Class of Potent Antithrombotics”, The Journal of Pharmacology and Experimental Therapeutics, vol. 292, No. 1, pp. 351-357, (2000).
Fareed, J. et al., “New antithrombotic drugs: A perspective”, Current Opinion in Cardiovascular, Pulmonary & Renal Investigational Drugs, vol. 1, No. 1, pp. 40-55, (1999).
Herbert, J.M., et al., “DX 9065A, a Novel, Synthetic, Selective and Orally Active Inhibitor of Factor Xa: In Vitro and In Vivo Studies”, The Journal of Pharmacology and Experimental Therapeutics, vol. 276, No. 3, pp. 1030-1038, (1996).
Nagahara, T. et al., “Design, Synthesis and Biological Activities of Orally Active Coagulation Factor Xa Inhibitors”, Eur. J. Med. Chem. vol. 30 (Supplemental), pp. 140s-143s, (1995).
Ewing, W.R., et al., “Progress in the design of inhibitors of coagulation factor Xa”, Drugs of the Future, vol. 24, No. 7, pp. 771-787, (1999).
Al-Obeidi, F., et al., “Factor Xa inhibitors”, Exp. Opin. Ther. Patents, vol. 9, No. 7, pp. 931-953, (1999).
Krishnamurti, C., et al., “Reduction of blood loss by infusion of human platelets in a rabbit kidney injury model”, Transfusion, vol. 39, pp. 967-974, (Sep. 1999).
Abendschein, D.R., et al., “Effects of ZK-807834, a Novel Inhibitor of Factor Xa, on Arterial and Venous Thrombosis in Rabbits”, J. Cardiovasc. Pharmacol., vol. 35, No. 5, pp. 796-805, retrieved Oct. 11, 2006, <http:\\gateway.ut.ovid.com.gw1/ovidweb.cgi>, May 2000.
Ostrem, J.A., et al., “Discovery of a Novel, Potent, and Specific Family of Factor Xa Inhibitors via Combinatorial Chemistry”, Biochemistry, vol. 37, No. 4, pp. 1053-1059, 1998.
Mousa, Shaker A., et al., “Comparison of the Effect of Different Platelet GPIIb/IIa Antagonists on the Dynamics of Platelet/Fibrin-Mediated Clot Strength Induced Using Thromboelastography”, Thrombosis Research, Jul. 3, 2001, vol. 104, pp. 49-56.
Gao, C et al., “Eptifibatide-induced thrombocytopenia and thrombosis in humas require FcγRIIa and the integrin β3 cytoplasmic domain”, The Journal of Clinical Investigation, Mar. 2009, vol. 11(3):504-511.
Beilfu, A et al., “Differential Effects of Factor IIa Inhibitors on the Endogenous Thrombin Potential”, Therapeutic Drug Monitoring, Dec. 2008, vol. 30(6):740-743. (Abstract).
International Search Report (International Application No. PCT/US2010/037203, filed Jun. 3, 2010).
Written Opinion of the International Search Authority (International Application No. PCT/US2010/037203, filed Jun. 3, 2010).
Mousa Shaker
Sehgal Lakshman R.
Andrews & Kurth LLP
Biovec Transfusion, LLC
Saucier Sandra
Wang Ping
LandOfFree
Platelet preservation composition containing eptifibatide, a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Platelet preservation composition containing eptifibatide, a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platelet preservation composition containing eptifibatide, a... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2686037