Platelet GPIII P1.sup.A1 and P1.sup.A2 epitopes, their preparati

Details Platelet GPIII P1.sup.A1 and P1.sup.A2 epitopes, their preparati Platelet GPIII P1.sup.A1 and P1.sup.A2 epitopes, their preparati

1991-12-09

1999-08-17

Caputa, Anthony C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530300, 530350, 530380, 530381, A61K 3800, A61K 3514, C07K 500, C07K 100

Patent

active

059395249

ABSTRACT:
Polypeptides and fusion polypeptides that immunologically mimic the native Pl.sup.A1 and Pl.sup.A2 determinants of platelet protein GPIIIa are disclosed. Also disclosed are DNA segments and recombinant DNA molecules that encode those polypeptides and fusion polypeptides and methods for expressing and using those determinants. Antibodies that immunoreact with one determinant or the other, but not both are also disclosed, as are methods of preparing and using those antibodies.

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