Platelet function inhibiting monoclonal antibody fragment

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303882, C07K 1528, C12P 2108

Patent

active

054400201

ABSTRACT:
There is provided a novel monoclonal antibody fragment which inhibits platelet function and may be useful in the treatment of thrombotic diseases. The fragment is produced by proteolytic digestion of the 7E3 monoclonal antibody.

REFERENCES:
patent: 5225181 (1993-07-01), Srivasta et al.
Marchalonis et al. Antibody as a Tool John Wiley; pp. 224, 465 1982).
Vainchecker et al. Blod 59(3): 514-21 (1982).
Coller Blood 58 (Suppl.) p. 191(a) Abstract 674 (1981).
Thrlow et al. Br. J. Haematol 55(1): 123-34 (1983).
Pidard et al. J Biol Chem 258(2): 12581-6 (1983).
Coller et al. J Clin Invest. 72:325-338 (1983).
Jones et al. Br. J. Haematol 57: 621-631 (1984).
Coller J Clin Invest 76: 101-108 (1985).

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