Platelet endothelial cell adhesion molecule-1 promoters and uses

Details Platelet endothelial cell adhesion molecule-1 promoters and uses Platelet endothelial cell adhesion molecule-1 promoters and uses

1994-07-05

1997-09-16

Adams, Donald E.

Chemistry: molecular biology and microbiology

Vector, per se

536 241, C12N 1563, C07H 2104

Patent

active

056680120

ABSTRACT:
Novel, substantially isolated isoforms of human platelet-endothelial cell adhesion molecule-1's, DNAs coding for transcripts that encode the novel isoforms and others, including a previously identified soluble isoform, methods of using such DNAs to make isoforms by expressing the DNA's, and promoter segments controlling transcription of human platelet-endothelial cell adhesion molecule-1 genes are provided. The novel isoforms differ from the complete human platelet-endothelial cell adhesion molecule-1's in lacking one or more segments near the C-terminus encoded by exons 10-15 of the genes for the full length molecules and arise in vivo from alternative splicing of the transcript from the genes.

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