Platelet derived growth factor antagonists

Details Platelet derived growth factor antagonists Platelet derived growth factor antagonists

1992-11-16

1995-08-22

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530327, 530399, 530402, 530408, 530350, 930120, C07K 1300, C07K 700, C07K 9900

Patent

active

054441510

ABSTRACT:
The invention describes antagonists for PDGF. The antagonists contain amino acids, and may be monomers or dimers. Especially preferred are dimers which bind the PDGF receptors, but prevent dimerization of the bound receptors. Dimerization is necessary for PDGF effect, hence the antagonistic effect. Also described are nucleic acid sequences for making the antagonists, as well as cell lines transfected with the material.

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Betsholtz, C. et al., Nature, 320: 695-699, 1986.
Ostman, A. et al., J. Biol. Chem., 266(16): 10073-10077, 1991.
LaRochelle, W. et al., Science, 248: 1541-1544, 1990.

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