Platelet-derived growth factor analogues

Details Platelet-derived growth factor analogues Platelet-derived growth factor analogues

1996-04-19

1999-09-14

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 13, 514 12, 530326, 530327, 530328, 530399, 4241851, A61K 3810, C07K 700

Patent

active

059523042

ABSTRACT:
Novel peptide analogues of platelet-derived growth factor, for use in inhibiting or stimulating growth and/or chemotaxis of cells, e.g., smooth muscle cells, are provided. Also provided are compositions of matter comprising those peptide analogues.

REFERENCES:
patent: 5326695 (1994-07-01), Andersson et al.
patent: 5591587 (1997-01-01), Niman
Betsholz, et al., cDNA Sequence and Chromosomal Localization of Human Platelet-Derived Groth Factor A-Chain and Its Expression in Tumor Cell Lines, Nature, vol. 320 No. 24, pp. 695-699, Apr. 1986.
Fenstermaker et al., "A Cationic Region of the Platelet-derived Growth Factor (PDGF) A-chain (Arg.sup.159 -Lys.sup.160 -Lys.sup.161) Is Required for Receptor Binding and Mitogenic Activity of the PDGF-AA Homodimer," The Journal of Biological Chemistry, 268(14):10482-10489 (May 1993).
Engstrom et al., "Identification of a Peptide Antagonist for Platelet-Derived Growth Factor," The Journal of Biological Chemistry, 267(23):16581-16587 (1992).

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