Platelet derived growth factor agonists

Details Platelet derived growth factor agonists Platelet derived growth factor agonists

1992-05-15

1994-07-05

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435244, 435243, 4352401, 4353201, 536 235, 536 2351, 530350, 530399, C12N 500, C12N 1500, C12P 2100

Patent

active

053266951

ABSTRACT:
The invention described PDGF modifiers. These are peptides which are derived from wild type PDGF monomers, and function as either agonists or antagonists. Various uses of these are described, as well as recombinant means of production. PDGF-B agonists comprising amino acids 97-180 of the PDGF-B monomer having the cysteines at amino acid residues 124 and 133 substituted, nucleic acid molecules encoding the agonists, plasmids, transformed host cells, and methods for causing receptor dimerization and autophosphorylation in a cell having PDGF-.beta. receptors on its surface comprising administering the PDGF-B agonist form part of the invention.

REFERENCES:
patent: 4845075 (1989-07-01), Murray et al.
patent: 4889919 (1989-12-01), Murray et al.
patent: 4959314 (1990-09-01), Mark et al.
patent: 5128321 (1992-07-01), Murray et al.
patent: 5132408 (1992-07-01), Baird et al.
patent: 5149691 (1992-09-01), Rutherford
Claesson-Welsh, PNAS, 86:4917-21, 1989.
Betsholtz, C. et al., Nature, 320:695-699, 1986.
Heldin et al., Cell Reg. 1: 555-566 (Jul. 1990).
Ostman et al., J. Biol. Chem. 263: 16202-16208 (1988).
Truett et al., DNA (4(5): 333-349 (1985).
Ostman et al., Cell Regul. 2:503-512, 1991.

Affiliated with

Also associated with

Rating

Platelet derived growth factor agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Platelet derived growth factor agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platelet derived growth factor agonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-795660