Platelet composition having improved storage stability and metho

Details Platelet composition having improved storage stability and metho Platelet composition having improved storage stability and metho

1980-09-17

1982-08-17

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

435 2, A61K 3544

Patent

active

043449360

ABSTRACT:
There is disclosed, in one aspect, a composition for improving the storage stability of blood platelets comprising the platelets, a container for the platelets, and a sialyl compound having the structural formula (I) ##STR1## wherein Ac is an acetyl group, R is a carbohydrate group, n is an integer of 1 or more, preferably 1, and the R and N-acetyl groups replace hydrogen atoms or hydroxyl groups on the ring. In another aspect, there is disclosed a method for increasing the storage stability of these platelets. This method comprises admixing with the platelets a compound having the structural formula (I) described above, wherein Ac, R, and n have the meanings described above.

REFERENCES:
Kovacs et al.-Chem. Abst. vol. 92 (1980) p. 104,180z.
Davis et al.-Chem. Abst. vol. 78 (1973) p. 92,819k.

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