Platelet cell adhesion molecule and variants thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 235, C07H 2100, C12N 1512

Patent

active

059170301

ABSTRACT:
A glycoprotein, PECAM-1, and variants thereof can be obtained by expression in a transformed host cell of a polynucleotide coding for the glycoprotein or a variant polypeptide. PECAM-1 can also be isolated from cellular sources. An antibody specific for PECAM-1 or a PECAM variant can be produced via recombinant techniques, or can be obtained from a hybridoma.

REFERENCES:
Seed et al 1987 P.N.A.S. 84: 3365-3369.
Goyert et al 1986 J Immunol 137: 3909-3914.
Muller et al 1989 J Exp Med 170: 399-414.

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