Platelet analysis in whole blood

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 2, 435 71, 435 721, 435 78, 435960, 435973, 436503, 436579, 53038822, 53038825, C12Q 100, G01N 3353, G01N 33567, G01N 33554, A01N 102, A61K 3514, C07K 300, C07K 1300

Patent

active

052468321

ABSTRACT:
Method of determining, in a blood sample, containing unwashed platelets and fibrinogen, the state of thrombin reactivity of the platelets by adding thrombin to the sample in the presence of an agent for inhibiting fibrin polymerization, and then detecting activated platelets.

REFERENCES:
Michelson et al (1987) Thrombin Induced Charges . . . Blood 70: 1673-1678.
Sanford et al (1987) Detection of Actuated . . . Blood 70: 307-315.
Adelman et al (1988) Abstract Blood 72(5) 1530-1535.
Ault et al (1989) Correlated Measurement . . . Cytometry 10: 448-455.
Adelman et al (1985) Abstract Blood 66(2) 423-7.
Michelson (1987) Flow Cytometric Analysis . . . J Lab Clin Med 110: 346-354.
Yamamoto et al (1991) Abstract Blood 77(8) 1740-1748.
Sims et al (1991) Abstract J Biol Chem 266(12) 7345-52.
Sanford et al (Jan. 1989) Epinepherin Induces . . . Blood 73: 150-158.
Nomura et al (Aug. 1989) Abstract Nippon Katsueki Gakkai Zasshi 52(5) 895.
Lengrae et al (Apr. 1989) Studies on the Mechanism . . . Blood 73: 1226-1234.
Michelson et al (1991) Abstract Blood 77(4) 770-779.
Charles S. Abrams, et al., "Direct Detection of Activated Platelets and Platelet-Derived Microparticles in Humans", Blood, vol. 75, No. 1 (Jan. 1) 1990; 128-138.
Miraglia et al., "Measurement of Blood Coagulation Factor XIIIa Formation in Plasma Containing Glycyl-L-prolyl-L-arginyl-L-proline", 144:165, 1985.
Johnston et al., "Heterogeneity of Platelet Secretion in Response to Thrombin Demonstrate by Fluorescence Flow Cytometry", Blood 69:1401, 1987.
George et al., "Platelet Surface Glycoproteins", J. Clin. Invest. 78:340, 1986.
Michelson et al., "Thrombin-Induced Changes in Platelet Membrane Glycoproteins Ib, IX, and IIb-IIIa Complex", Blood 70:5 (1987) pp. 1673-1678.
Shattil et al., "Detection of Activated Platelets in Whole Blood Using Activation-Dependent Monoclonal Antibodies and Flow cytometry", Blood 70:307 (1987).
Vickers et al., "Phosphatidylinositol 4,5-bisphosphate is selectively retained by platelet-fibrin clots Formed by Thrombin", Biochem, J. 245:649 (1987).
Harfenist et al., "The use of the synthetic Peptide, gly-Pro-Arg-Pro, in the Preparation of Thrombin-degranulated Rabbit Platelets", Blood 59-952 (1982).
Ault et al., "Correlated Measurement of Platelet Release and Aggregation in Whole Blood", Cytometry 10:448 (1989).
Frishman et al., "Reversal of Abnormal Platelet Aggregability and Change in Exercise Tolerance in Patients with Angina Pectoris Following Oral Propranolol", Circulation 50:887 (1974).
Sagel et al., "Increased Platelet Aggregation in Early Diabetus Mellitus", Annals of Internal Medicine 82:733 (1975).
Carbalho et al., "Platelet Function in Hyperlioproteinemia", New Eng. J. of Med. 290:434 (1974).
Hawkins, "Smoking, Platelets and Thrombosis", Nature 236:450 (1972).
Levine et al., "Platelet Activation and Secretion Associated with Emotional Stress", Circulation 71:1129 (1985).
LeGrand et al., "Studies on the Mechanism of Expression of Secreted Fibrinogen on the surface of activated Human Platelets", Blood 73:1226-1234 (1989).
Kaplan et al., "Effect of Fibrin on Endothelial Cell Production of Prostacyclin and Tissue Plasminogen Activator", Arterioschlerosis 9:43 (1989).
Hantgan, "Fibrin protofibril and fibrinogen binding to ADP-stimulated platelets: evidence for a common Mechanism", Biochemica et Biophysics Acta 968:24 (1988).
Jen et al., "Direct platelet-fibrin interaction that does not require platelet activation", Am. J. Physiology 253:H745 (1987).
Achyuthan et a
Funding for this invention was provided by a grant from the National Institute of Health, and the Federal Government has certain rights in the invention.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Platelet analysis in whole blood does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Platelet analysis in whole blood, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platelet analysis in whole blood will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1049012

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.