Platelet aggregation inhibitors having high specificity for GPII

Details Platelet aggregation inhibitors having high specificity for GPII Platelet aggregation inhibitors having high specificity for GPII

1994-09-23

1996-02-20

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530329, 530330, 930270, C07K 500, C07K 700, C07K 1700

Patent

active

054930073

ABSTRACT:
A peptide containing the tripeptide recognition sequences RGD or KGD in a cycle and an exocyclic group bearing a positive charge is provided. The compound is provided in therapeutic form for administration to a mammal and exhibits high specificity and potency as a platelet aggregation inhibitor without undesireable side effects.

REFERENCES:
patent: 4517686 (1985-05-01), Ruoslahti et al.
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4614517 (1986-09-01), Ruoslahti et al.
patent: 4661111 (1987-04-01), Ruoslahti et al.
patent: 4683291 (1987-07-01), Zimmerman et al.
patent: 4792525 (1988-12-01), Ruoslahti et al.
patent: 4857508 (1989-08-01), Adams et al.
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 5023233 (1991-06-01), Nutt et al.
patent: 5037808 (1991-08-01), Tjoeng et al.
patent: 5041380 (1991-08-01), Ruoslahti et al.
Ruggeri et al., Proc. Natl. Acad. Sci., 83: 5708-5712 (1986).
Bagdy et al, Thrombosis and Haemostasis vol. 67 pp. 325-330 (1992).
Ginsberg et al., J. Biol. Chem., 260: 3931-3936 (1985).
Pierschbacher et al., Proc. Natl. Acad. Sci., 81: 5985-5988 (1984).
Kloczewiak et al., Biochemistry, 23: 1767-1774 (1984).
Gartner, T. K. and Bennett, J. S., J. Biol. Chem., 260: 11891-11894 (1985).
Kieffer, N. and Phillips, D. R., Annu. Rev. Cell Biol., 36: 329-357 (1990).
Plow, et al., Proc. Natl. Acad. Sci. USA, 82: 8057-8061 (1985).
Pytela et al., Cell, 40: 191-198 (1985).
Pytela et al., Proc. Natl. Acad Sci. USA, 82: 5766-5770 (1985).
Pytela et al., Science, 231: 1559-1562 (1985).
Gardner et al., Cell, 42: 439-448 (1985).
Pierschbacher et al., Nature, 309: 30-33 (1984).
D'Souza et al., J. Biol. Chem., 263: 3943-3951 (1988).
Parise et al., J. Biol. Chem., 262: 12597-12602 (1987).
Toda et al., J. Cell. Biol., 105: 3097-3104 (1987).
Singer et al., J. Cell. Biol., 104: 573-584 (1987).
Lash et al., Develop Biol., 123: 411-420 (1987).
Haskel et al., Thromb. Res., 56: 687-695 (1989).
Haverstick et al., Blood, 66: 946-952 (1985).
Plow et al., Blood, 70: 110-115 (1987).
Ruoslahti et al., J. Clin. Invest., 87: 1-5 (1991).
Ali et al., Peptides Proc. 11th Amer. Peptide Symposium, La Jolla, CA, Marshall & Rivier, eds. (Jul. 9-14, 1989).
Pierschbacher et al., J. Biol. Chem., 262(36): 17294-17298 (1987).
Garsky et al., Pro. Natl. Acad. Sci. USA, 86: 4022-4026 (1989).
Dennis et al., Pro. Natl. Acad. Sci. USA, 87: 2471-2475 (1989).
Chao et al., Pro. Natl. Acad. Sci. USA, 86: 8050-8054 (1989).
Shebuski et al., J. Biol. Chem., 264: 21550-21556 (1989).
Gan et al., J. Biol. Chem., 263: 19827-19832 (1989).
Huang et al., Biochemistry, 28: 661-666 (1989).
Huang et al., J. Biol. Chem., 262: 16157-1613 (1987).
Joubert, Francois J. & Taljaard, Nico, Biochimica et Biophysica Acta, 579: 228-233 (1979).
Spatola, A. F. and Krzysztof, D., Tetrahedron, 44(3): 821-833 (1988).
Gero, T. and Spatola, A. F., Biochem. Biophys. Res. Comm., 120(3): 840-845 (1984).
Edwards, J. V. and Spatola, A. F., Biochem. Biophys. Res. Comm., 136(2): 730-736 (1986).
Spatola, A. F. and Edwards, J. V., Biopolymers, 25: s229-s244 (1986).
Davies et al., Biochem Soc. Trans., 18: 11326-11328 (1990).
Drickamer et al., J. Biol. Chem., 261: 6878-6887 (1986).
Rauvala et al., J. Cell Biol., 107: 2293-2305 (1988).
Maes et al., Fed. Europ. Biochem. Soc., 241: 41-45 (1988).
Moos et al., Nature, 334: 701-703 (1988).
Neurath et al., Mol. Immun., 27: 539-549 (1990).
Kirchofer et al., J. Biol. Chem., 265: 18525-18530 (1990).
Ratner et al., Nature, 313: 277-284 (1985).
Bond et al., Biochemistry, 28: 6110-6113 (1989).

Affiliated with

Also associated with

Rating

Platelet aggregation inhibitors having high specificity for GPII does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Platelet aggregation inhibitors having high specificity for GPII, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platelet aggregation inhibitors having high specificity for GPII will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1356925