Platelet aggregation inhibitors

Details Platelet aggregation inhibitors Platelet aggregation inhibitors

1995-06-07

1999-09-28

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435325, 4352523, 4353201, 536 235, C12P 2106, C12N 500, C12N 1500, C07K 1700

Patent

active

059587326

ABSTRACT:
An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K* -(G/Sar)-D wherein K* is a modified lysyl residue of the formula

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11th American Peptide Symposia, San Diego, California, Jul. 9-14, 1989.

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