Platelet aggregation inhibitors

Details Platelet aggregation inhibitors Platelet aggregation inhibitors

1995-06-05

1998-06-23

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 16, 530317, A61K 3800, A61K 3802, C07K 500, C07K 700

Patent

active

057705640

ABSTRACT:
An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* a modified lysyl residue of the formula

REFERENCES:
patent: 4652639 (1987-03-01), Stabinsky
patent: 5023233 (1991-06-01), Nutt
patent: 5338723 (1994-08-01), Nutt
patent: 5340798 (1994-08-01), Nutt
patent: 5374622 (1994-12-01), Nutt
Charon, et al., Synthetic Peptide with Antithrombotic Activity, Peptides, Chemistry, Structure and Biology, Proceedings of the Eleventh American Peptide Symposium, Jul. 9-14, 1989, La Jolla, CA, pp. 82-83.
Ginsberg, et al., Inhibition of Fibronectin Binding to Platelets by Proteolytic Fragments and Synthetic Peptides Which Support Fibroblast Adhesion, The Journal of Biological Chemistry, 260(7):3931-3936 (1985).
Hanson et al., Baboon Models of Acute Arterial Thrombosis, Thrombosis and Haemostatis, 58(3):801-805 (1987).
Hanson et al., Platelet Interaction with Dacron Vascular Grafts, Arteriosclerosis, 5:595-603 (Nov./Dec. 1985).
Huang et al., Mechanism of Action of the Platelet Aggregation Inhibitor Purified from Agkistrodon Halys (Mamushi) Snake Venom, Toxicon, 22:243-252 (1984).
Huang et al., Characterization of a Potent Platelet Aggregation Inhibitor from Agkistrodon Rhodostoma Snake Venom, Biochimica et Byophysica Acta 22789, 925:248-247 (1987).
Kosugi, et al., Isolation of Platelet Aggregation Inhibitor from Trimesurus Flavoridis Snake Venom, The Snake, 17:117-123 (1985).
Kumagai, et al., Effect of Cyclic RGD Peptide On Cell Adhesion and Tumor Metastasis, Biochemical and Biophysical Research Communications, 177(1):74-82 (1991).
Musial, et al., Inhibition of Platelet Adhesion to Surfaces of Extracorporeal Circuits by Disintegrins, Circulation, 82(1):262-273 (1990).
Niewiarowski et al., Inhibition of Platelet Adhesion to Surfaces of Extracorporeal Circuit by RGD Containing Peptides from Viper Venoms, Thrombosis and Haemostasis, 62;319, Abtract No. 853 (1989).
Nutt, et al., Development of Novel, Highly Selective Fibrinogen Receptor Antagonists as Potentially Useful antithrombotic Agents, Peptides, Chemistry and Biology, Proceedings of the Twelfth American Peptide Symposium, Jun. 16-21, 1991, Cambridge, MA, pp. 914-916.
Nutt, et al., Structure-and Conformation-Activity Studies Leading to Potent Fibrinogen Receptor Antagonists Containing Arg-Gly-Asp, Peptides, pp. 784-786 (1990).
Ouyang et al., A Potent Platelet Aggregation Inhibitor Purified from Agkistrodon Halys (Mamushi) Snake Venom, Toxicon, 21(6):797-804 (1983).
Samanen, et al., Development of a Small RGD Peptide Fibrinogen Receptor Antagonist with Potent Antiaggregatory Activity in Vitro, J. Med. Chem. 34:3114-3125 (1991).
Scarborough, et al., Barbourin A GPIIb-IIIa-Specific Integrin Antagonist from the Venom of Sistrurus M. Barbouri, The Journal of Biological Chemistry, 266(15):9359-9362 (1991).
Scarborough, Design of Potent and Specific Integrain Antagonists, J. Biol. Chem., 268:1066-1073 (1993).
Smith et al., Table 3.1 The Structures of the .alpha.-Amino Acids Commonly Found in Proteins, Principles of Biochemistry, 7th Edition, pp. 32-33, 1983, McGraw Hill.
Steiner et al., CA.sup.2+ -Dependent Binding of a Synthetic Arg-Gly-Asp (RGD) Peptide to a Single Siteon the Purified Platelet Glycoprotein IIb-IIIa Complex, J. Biol. Chem., 264(22):13102-13108 (1989).
Knudsen et al., Exp. Cell Res., vol. 179, pp. 42-49, 1988.
Smith et al, Principles of Biochemistry, 7th Ed., pp. 32-33, 1983.

Affiliated with

Also associated with

Rating

Platelet aggregation inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Platelet aggregation inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platelet aggregation inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1394769