Platelet aggregation inhibitors

Details Platelet aggregation inhibitors Platelet aggregation inhibitors

1993-07-12

1994-09-06

Baker, Keith

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

436503, 436504, 436 69, 435 71, 435 78, 435 793, 435 13, G01N 33566

Patent

active

053447832

ABSTRACT:
An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of the PAI in a wide range of snake venom samples were accomplished. The purified PAI from several of these active snake venoms is described. In addition, PAIs lacking the Arg-Gly-Asp adhesion sequence but containing Lys-Gly-Asp are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

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Shebuski et al., J. Biol. Chem. (1989) 264(36):21550-21556.
Ali et al., Peptides: Chemistry, Structure and Biology (Proceedings of the 11th American Peptide Symposium), Marshall, G. R. and River, J. E. editors, EXCOM, Leiden (1990).

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