Platelet aggregation inhibitors

Details Platelet aggregation inhibitors Platelet aggregation inhibitors

1995-06-07

1999-08-10

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 16, 530317, A61K 3800, A61K 3802, C07K 500, C07K 700

Patent

active

059359269

ABSTRACT:
An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula

REFERENCES:
Knudsen et al., Exp. Cell Research, vol. 179, pp. 42-49 (1988.

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